An All India Association of medical professionals was formed in the All India Medical Conference held in Calcutta at National Medical College on 28th December, 1928, with Dr. G.V. Deshmukh as President and Dr. Sir Nil Ratan Sarkar and Bharat Ratna Dr. B.C. Roy as Vice Presidents. The head office was in Calcutta. In 1930, the Association was renamed as Indian Medical Association ( IMA ).

Upto the session 1933-34, there were no State or Local branches of IMA. In the 1934-35 Session, precisely on 29th June, 1935, first Local Branch of IMA was formed at Calcutta and was named as IMA Calcutta branch. The first president was late Col. Prof. K.K. Chatterjee and first Secretary was Dr. Girin Banerjee. The branch has completed 75 years on 29th June, 2010.

IMA Calcutta Branch has many luminaries in its membership. It has given many National Presidents of IMA, namely Dr. B.C. Roy, Sir Nil Ratan Sarkar, Dr. K.S. Roy, Dr. Capt. P.B. Mukherjee, Dr. A.C. Ukil, Dr. B.P. Tripathi, Dr. Jyotirmoy Majumdar, Dr. Bhaskar Roy Choudhury and Dr. Sudipto Roy. There are many others who served the association with utmost dedication and commitment but could not become National President.
Diamond Jubilee of the branch was celebrated on 10th and 11th August,1996 in a befitting manner. It was inaugurated by His excellency Governor of West Bengal Shri K.V. Ragunath Reddy in the presence of many dignitaries.

The branch is now preparing for Platinum Jubilee celebrations.